Saint Joseph's University Center for Undergraduate Research

Lysosomal Uptake of a 10 kDa Fluorescent Dextran in Triple Negative Breast Cancer Cells

Fluorescence microscopy of MDA-MB-231 TNBC cells reveals lysosomal uptake of Alexa Fluor DAF 488, emphasizing a potential pathway for targeted cancer treatment.

***WINNER OF THE MOST POPULAR VOTES***

Emma Clift, Grace Ho, and Shay Patel

Mentor: Dr. Clyde Ofner III, Department of Pharmaceutical Sciences

Brightfield and Fluorescence Imaging of MDA-MB-231 Tumor Spheroids in 3D Cell Culture

MDA-MB-231 tumor spheroids were grown in a 3-dimensional cell culture and imaged using brightfield and fluorescence microscopy. Blue indicates live nuclei, while green represents dead cells.

Alyssa Weisberg, Branden Stanley, and Gwyneth Shermanski

Mentors: Dr. Isabelle Mercier, Dr. Adeboye Adejare, Department of Pharmaceutical Sciences

Seeing is Believing: Visual Storytelling in Creative Nonfiction

An illustration inspired by Sanelli's memories of reading comic strips with his mother. Inspired by Bill Watterson.

***WINNER OF THE BEST IMAGE (determined by faculty votes)***

Luke Sanelli

Mentor: Dr. Jenny Spinner, Department of English, Writing and Journalism

Unveiling Molecular Secrets: Advancing Mass Spectrometry for Surface Analysis

This mass spectrometry data showcases the development of a novel Surface Reader, designed for rapid, non-invasive detection of biomolecules and bacterial markers directly from surfaces.

Jessalyn Aquilino

Mentor: Dr. Charles McEwen, Department of Chemistry and Biochemistry

Transgenic Caenorhabditis elegans Isolated Under Fluorescent Microscopy with Green Fluorescent Protein

C. elegans (STR 198) showing dopaminergic neurons in ventral and dorsal nerve cords, depicting C. elegans lacking neurodegeneration. Mg x4 EVOS FL Auto.

Shawan Finck

Mentor: Dr. Adeboye Adejare, Department of Pharmaceutical Sciences

Highlighting Dopaminergic Neurons in the BZ555 Strain of C. elegans

Image of a C. elegans treated with a hazardous compound, calcium carbide. The stain used here highlights dopaminergic neurons.

Kaitlin Dixon

Mentor: Dr. Adeboye Adejare, Department of Pharmaceutical Sciences

Danio rerio inspection of swimming patterns.

Danio rerio are a fish who depict schooling behaviors, patterned synchronized swimming, as opposed to shoaling behavior, the loose grouping of fish.

Grace Roth

Mentor: Dr. Scott McRobert, Department of Biology

Platys in the Lab.

Platys, a species of fish that display the typical behavior of grouping together, called shoaling, come in all types of interesting phenotypes that can be used in different research assays.

Grace Roth

Mentor: Dr. Scott McRobert, Department of Biology

Flow region around a sphere

Flow region around a sphere visualized using streamlines

Matthew McGrath

Mentor: Dr. Piotr Habdas, Department of Physics

Murine hippocampal neurons and glia

Matrix of neurons and glia (A) from neonatal brain tissue (beta-tubulin, green; DAPI, blue; G3BP1, red). Individual neurons (B & C) are visualized among the nuclei from AraC-treated cells.

Bridget Magee

Mentor: Dr. Jennifer Tudor

Terfenadine-Induced Lysosomal Membrane Permeabilization in Non-Malignant Breast Tissue Cells

This study tests whether terfenadine, an antihistamine drug, can trigger lysosomal membrane permeabilization in triple-negative breast cancer and healthy breast cells as a potential targeted therapy.

Emma Clift

Mentor: Dr. Clyde Ofner III, Department of Pharmaceutical Sciences